Educational Programs for Perfusionists
Cardiac Surgical Outcomes & the Role of Antithrombin
TARGET AUDIENCE
Anesthesiologists and Perfusionists
COST
This program is free for all participants.
FACULTY
Marco Ranucci, MD
Department of Cardiothoracic
Anesthesia and Intensive Care
Istituto Policlinico S. Donato
Milan, Italy
Bruce Spiess, MD
Professor
Chief of Cardiothoracic Anesthesia
Director of Research in the Department of Anesthesiology
Virginia Commonwealth University
Richmond, VA
PROGRAM OVERVIEW
Cardiac surgery with cardiopulmonary bypass (CPB) is associated with hemostatic and inflammatory alterations that may lead to severe bleeding, thromboembolic events, whole-body inflammatory reactions, and death. Patients may experience a prothrombotic-hemorrhagic syndrome accompanied by a systemic inflammatory reaction that is similar in character to a severe sepsis. Potent anticoagulation is therefore an important component of CPB.
Despite the recent introduction of new direct thrombin inhibitors, heparin remains the standard anticoagulant during CPB. However, heparin resistance, which is thought to be related to acquired antithrombin deficiency, is a common clinical problem that may result in a severe deterioration of the outcome in cardiac operations.
With a growing corpus of literature investigating the close interactions between the hemostatic and inflammatory systems, the anticoagulant and anti-inflammatory agent antithrombin has become a major target for pharmacologic manipulation in cardiac surgery. This symposium will provide information on the role of antithrombin in cardiac operations with cardiopulmonary bypass and the implications of low antithrombin levels on surgical outcomes. It will also examine the role of genetics and the inflammatory response on specific outcomes and determine the key areas towards which future research should be directed.
LEARNING OBJECTIVES
At the conclusion of this program, participants should be able to:
- Recognize genetic influences that may impact crucially on the outcome of cardiac surgical procedures and the development of post-surgical disorders
- Describe the latest information on the role of antithrombin in cardiac operations both in the United States and abroad
- Articulate the predictive value and clinical effect of low antithrombin levels at admission to the intensive care unit
- Summarize the impact of anticoagulation management in cardiopulmonary bypass on the inflammatory system and inflammatory response
TO RECEIVE CREDIT FOR THIS PROGRAM
Review the program information on this page.
- Review the slide program.
- Complete the CME post-test and evaluation and registration information. Please note you must click on the link on the last slide to access the post-test and evaluation.
- Your certificate will be available online immediately.
PARTICIPATION
This activity involves a slide presentation that needs to be reviewed in its entirety. You may print a copy of the presentation from the attachment section of the program once you launch the slide presentation.
The estimated time to complete this activity, including review of the materials, is 2.0 hours.
ACCREDITATION
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of The University of Nebraska Medical Center, Center for Continuing Education and the Institute for Health Protection.
The University of Nebraska Medical Center, Center for Continuing Education is accredited by the ACCME to provide continuing medical education for physicians.
The University of Nebraska Medical Center, Center for Continuing Education designates this educational activity for a maximum of 2.0 AMA PRA Category 1 Credit(s)â„¢. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Perfusionist Credit: This course has been approved for 1.6 Category 1 credits by the American Board of Cardiovascular Perfusion.
TERM OF APPROVAL
Original release date: June 2007
EXPIRATION
June 30, 2008
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